Year : 2020 | Volume
: 33 | Issue : 2 | Page : 699--705
The prognostic value of Glasgow prognostic score in epithelial ovarian cancer
Tarek A Hashem1, Mohammad A Shehata1, Suzan A Alhassanin1, Salma M El-Menshawy2, Suzy F Gohar1
1 Department of Clinical Oncology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Meet Ghamr Oncology Center, Ministry of Health, Meet Ghamr, Dakahlia, Egypt
In this study, the authors assessed the prognostic value of Glasgow prognostic score (GPS) in overall survival (OS) and progression-free survival.
Inflammation plays an important role in the pathogenesis of ovarian cancer. The GPS is an inflammation-based prognostic score composed of C-reactive protein and albumin.
Patients and methods
A prospective study was conducted in the Department of Clinical Oncology, Menoufia University, between June 2016 and December 2018. The authors analyzed the clinicopathological characteristics and pretreatment C-reactive protein and serum albumin levels of 57 patients with epithelial ovarian cancer. Time to treatment failure and OS were determined using Kaplan–Meier method.
High GPS was significantly associated with age, performance status, elevated Ca125 level, advanced stage, ascites, size of residual tumor after the debulking surgery, and platinum sensitivity (P < 0.001). In addition, patients with higher GPS had shorter progression-free survival (P < 0.001) and OS (P = 0.107). However, multivariate analysis revealed that GPS is not an independent prognostic factor in those group of patients.
High GPS is a poor prognostic factor in patients with epithelial ovarian cancer.
Salma M El-Menshawy
|How to cite this article:|
Hashem TA, Shehata MA, Alhassanin SA, El-Menshawy SM, Gohar SF. The prognostic value of Glasgow prognostic score in epithelial ovarian cancer.Menoufia Med J 2020;33:699-705
|How to cite this URL:|
Hashem TA, Shehata MA, Alhassanin SA, El-Menshawy SM, Gohar SF. The prognostic value of Glasgow prognostic score in epithelial ovarian cancer. Menoufia Med J [serial online] 2020 [cited 2020 Nov 25 ];33:699-705
Available from: http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2020;volume=33;issue=2;spage=699;epage=705;aulast=Hashem;type=0