Year : 2019 | Volume
: 32 | Issue : 3 | Page : 751--755
The role of osteopontin in dermatological diseases
Alaa H Marea1, Wafaa A Shehata1, Sally M El-Hefnawy2, Amany M Mohsen3
1 Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufia University, Shebeen El-Kom, Egypt
2 Department of Medical Biochemistry, Faculty of Medicine, Menoufia University, Shebeen El-Kom, Egypt
3 Department of Dermatology, New Cairo Hospital, Cairo Health Sector, Cairo, Egypt
The aim of this study was to study the role of osteopontin (OPN) in dermatological diseases through a meta-analysis study.
Previous literatures, reviews, and studies as well as medical websites (PubMed, Medscape and Science Direct), all material available in the internet from 2014 to 2017, and scientific journals databases were searched from the start date of each database.
The initial search presented 10 articles of which five met the inclusion criteria. Selection was done by supervisors for studying the role of OPN in dermatological diseases.
If the studies did not fulfill the inclusion criteria, they were excluded. Study quality assessment included whether ethical approval was gained, eligibility criteria specified, appropriate controls, adequate information, and defined assessment measures.
Comparisons were made by a structured review with the results tabulated.
In total five potentially relevant publications were included; all were human studies. The studies show an elevated level of OPN in some dermatological diseases such as allergic contact dermatitis, alopecia areata, psoriasis, sarcoidosis, and systemic lupus erythematosus in comparison to the controls.
As OPN was elevated among allergic contact dermatitis, alopecia areata, psoriasis, sarcoidosis, and systemic lupus erythematosus patients, it may play a role in the pathogenesis of such diseases.
Amany M Mohsen
9 Elsawaf Street, Sector-10, Naser City, Cairo 11528
|How to cite this article:|
Marea AH, Shehata WA, El-Hefnawy SM, Mohsen AM. The role of osteopontin in dermatological diseases.Menoufia Med J 2019;32:751-755
|How to cite this URL:|
Marea AH, Shehata WA, El-Hefnawy SM, Mohsen AM. The role of osteopontin in dermatological diseases. Menoufia Med J [serial online] 2019 [cited 2019 Dec 13 ];32:751-755
Available from: http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2019;volume=32;issue=3;spage=751;epage=755;aulast=Marea;type=0