Menoufia Medical Journal

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 32  |  Issue : 2  |  Page : 723--728

The role of autologous platelet-rich plasma in healing of gaping and chronic wounds


Mohamed A Megahed1, Tarek M Rageh2, Ahmed T Nassar1, Mohamed El-Sayed Abdel Razek3 
1 Department of Plastic Surgery, Menoufia University, Shebin El Kom Teaching Hospital, Shebin El Kom, Egypt
2 Department of General Surgery Department, Menoufia University, Shebin El Kom Teaching Hospital, Shebin El Kom, Egypt
3 Department of Plastic Surgery Department, Shebin El Kom Teaching Hospital, Shebin El Kom, Egypt

Correspondence Address:
Mohamed El-Sayed Abdel Razek
Tanta
Egypt

Objective The aim was to evaluate the efficacy of platelet-rich plasma (PRP) in the treatment of gaping and chronic wounds. Background Nonhealing ulcers are a major health problem with high cost in terms of human and material resources. Application of autologous PRP has been a major breakthrough for the treatment of nonhealing ulcers, as it is an easy and cost-effective method and provides the necessary growth factors that enhance wound healing. Patients and methods A study was performed on 28 patients with nonhealing ulcers of various etiologies. Overall, 19 patients were treated with PRP at weekly intervals for a maximum of seven treatments and nine patients were treated with saline gauze dressings on alternative days. At the end of the 7, 14, 21, and 28-day periods, reduction in size of the ulcers (area and volume) was assessed and followed up till the healing completed, and the patients were followed up for a period of 12 weeks after treatment. Results The mean age ± SD of the patients was 39.68 ± 12.11 years. Of 19 ulcers in study group, there were two venous ulcers, nine traumatic ulcers, five pressure ulcers, and three diabetic ulcers. The mean ± SD duration of healing of the ulcers was 49.84 ± 22.23 days in study group and 108.67 ± 5.64 days in control group (P < 0.001). Conclusion Conventional therapies do not provide satisfactory healing for chronic nonhealing ulcers as they are not able to provide the necessary growth factors essential for the healing process. PRP is a safe, affordable, biocompatible, and simple office-based procedure for the treatment of nonhealing ulcers.


How to cite this article:
Megahed MA, Rageh TM, Nassar AT, Abdel Razek ME. The role of autologous platelet-rich plasma in healing of gaping and chronic wounds.Menoufia Med J 2019;32:723-728


How to cite this URL:
Megahed MA, Rageh TM, Nassar AT, Abdel Razek ME. The role of autologous platelet-rich plasma in healing of gaping and chronic wounds. Menoufia Med J [serial online] 2019 [cited 2019 Nov 18 ];32:723-728
Available from: http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2019;volume=32;issue=2;spage=723;epage=728;aulast=Megahed;type=0