Menoufia Medical Journal

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 32  |  Issue : 2  |  Page : 417--422

Traumatic brain injury: serum S-100B protein measurement related to neuroradiological findings


Nagwa M Doha1, Amany S Ammar1, Mohammed M El-Mashad2, Ahmed A Metwally3 
1 Department of Anesthesiology, Intensive Care and Pain Management, Faculty of Medicine, Menoufia University, Shebeen El-Kom, Egypt
2 Department of Neurosurgery, Faculty of Medicine, Menoufia University, Shebeen El-Kom, Egypt
3 Department of Critical Care, Sheben El Koum Teaching Hospital, Shebeen El-Kom, Egypt

Correspondence Address:
Ahmed A Metwally
Saad Zaghlol Street, Tala, Menoufia 32611
Egypt

Objective The aim of this study was to estimate the level of S-100B protein as a biological marker and to assess its sensitivity in the detection and prediction of outcome of traumatic brain injury (TBI) patients compared with radiological and clinical scores. Background TBI has a tremendous impact on public health. S-100B protein increases in cases of TBI and does not increase in nonbrain injuries. S-100B has been found to correlate with the severity of head injury. Patients and methods The study was a prospective, randomized, controlled study. Forty critical patients were divided into two groups; group I had 20 patients with TBI and group II had 20 patients with head-free trauma. Group I had a sampling of serum S-100B at day 1, 3, 5, and at discharge, and the results were correlated with computed tomography brain findings, Glasgow Coma Scale, and outcome. Group II had a sampling of serum S-100B at day 1, and the result was correlated with the results of group I. Results Significant difference between the results of S-100B in group I and group II was detected (P < 0.001), with higher results of S-100B in TBI patients. Significant difference between the results of S-100B in survival and nonsurvival for patients in group I was detected (P = 0.002), with higher results of S-100B in nonsurvival patients. Significant correlation between the results of S-100B and Glasgow Coma Scale in group I was detected (P = 0.002). Conclusion S-100B is a prognostic marker in TBI, specific to TBI, and not correlated to the findings in computed tomography brain.


How to cite this article:
Doha NM, Ammar AS, El-Mashad MM, Metwally AA. Traumatic brain injury: serum S-100B protein measurement related to neuroradiological findings.Menoufia Med J 2019;32:417-422


How to cite this URL:
Doha NM, Ammar AS, El-Mashad MM, Metwally AA. Traumatic brain injury: serum S-100B protein measurement related to neuroradiological findings. Menoufia Med J [serial online] 2019 [cited 2019 Nov 21 ];32:417-422
Available from: http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2019;volume=32;issue=2;spage=417;epage=422;aulast=Doha;type=0