Year : 2018 | Volume
: 31 | Issue : 2 | Page : 449--454
Red blood cell distribution width to estimate lupus activity
Sabry A Shoeib, Mohamed A Abd Elhafez, Alaa E Abd El-Hamed, Heba G Sherief
Department of Internal Medicine, Faculty of Medicine, Menoufiya University, Shebeen El-Kom, Egypt
The aim of the study was to study red blood cell distribution width (RDW) in systemic lupus erythematous (SLE) patients as a lupus activity marker.
SLE is a multifactorial systemic autoimmune disease that can affect multiple organs. The general pathogenesis of this disease still needs a better understanding. RDW is a measure of the red blood cell size variation.
Patient and methods
This prospective study was carried in the Internal Medicine Department, Menoufia University Hospital, from March 2016 to August 2016. Our study included 58 patients with SLE activity, which was measured using the Systemic Lupus Erythematous Disease Activity Index. RDW was measured as one of the parameters of complete blood count. RDW was reported on the Sysmex XT. In this study we excluded any other causes of anemia and other connective tissue diseases.
The study included 58 SLE patients: 20 systemic lupus patients with high activity and 38 systemic lupus patients with very high activity. RDW was higher in systemic lupus patients with very high activity than in systemic lupus patients with high activity. There was a highly significant correlation between RDW and Systemic Lupus Erythematous Disease Activity Index. There was a highly significant correlation between RDW and erythrocyte sedimentation rate.
There was statistically higher RDW in lupus patients with very high activity than in those with high activity; therefore, RDW can be used as a lupus activity marker. RDW was associated with the inflammatory process of SLE.
Heba G Sherief
Kafe Shanawan, Shebeen El-Kom, Menoufia
|How to cite this article:|
Shoeib SA, Abd Elhafez MA, Abd El-Hamed AE, Sherief HG. Red blood cell distribution width to estimate lupus activity.Menoufia Med J 2018;31:449-454
|How to cite this URL:|
Shoeib SA, Abd Elhafez MA, Abd El-Hamed AE, Sherief HG. Red blood cell distribution width to estimate lupus activity. Menoufia Med J [serial online] 2018 [cited 2020 Apr 2 ];31:449-454
Available from: http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2018;volume=31;issue=2;spage=449;epage=454;aulast=Shoeib;type=0