Menoufia Medical Journal

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 29  |  Issue : 4  |  Page : 818--825

Study of interleukin-22 in patients with psoriasis in Menoufia University Hospitals


Ghada R El-Hendawy1, Ahmed A Salama1, Mohamed A Gaber2, Eman Mhros1 
1 Department of Microbiology and Immunology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Dermatology and Venereology, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Correspondence Address:
Eman Mhros
Shebin El Kom City, Menoufia Governorate, 32511
Egypt

Objectives The aim of this study was to detect a relation between serum levels of interleukin-22 (IL-22) in patients with psoriasis and also to detect a relation of IL-22 with psoriasis area and severity index (PASI). Background IL-22 is highly expressed in several different chronic inflammatory conditions, including psoriasis, inflammatory bowel disease, and rheumatoid arthritis. The best studied function for IL-22 is within the skin, as it has an inflammatory role during skin inflammation. Materials and methods The study was conducted on 40 patients with psoriasis and 20 age-matched and sex-matched healthy individuals. All patients were subjected to history taking and complete medical examination. Serum levels of IL-22 were measured by enzyme-linked immunosorbent assay technique. Serum levels of IL-22 were statistically analyzed in relation to PASI. Results The serum levels of IL-22 were highly elevated in patients with psoriasis compared with healthy people (P < 0.001). The serum IL-22 was significantly higher in patients with severe psoriasis as compared with those with mild and moderate psoriasis. The serum levels of IL-22 were significantly higher in patients with psoriasis experiencing itching as compared with those not experiencing itching (P < 0.001). There was no statistically significant difference between the serum levels of IL-22 and smoking. Conclusion The significant elevation in the serum level of IL-22 in patients with psoriasis when compared with that of healthy controls and the significant elevation in the serum levels of IL-22 with advanced PASI score are suggestive of IL-22 playing a fundamental role in pathogenesis of psoriasis.


How to cite this article:
El-Hendawy GR, Salama AA, Gaber MA, Mhros E. Study of interleukin-22 in patients with psoriasis in Menoufia University Hospitals.Menoufia Med J 2016;29:818-825


How to cite this URL:
El-Hendawy GR, Salama AA, Gaber MA, Mhros E. Study of interleukin-22 in patients with psoriasis in Menoufia University Hospitals. Menoufia Med J [serial online] 2016 [cited 2020 May 31 ];29:818-825
Available from: http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2016;volume=29;issue=4;spage=818;epage=825;aulast=El-Hendawy;type=0