Menoufia Medical Journal

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 27  |  Issue : 4  |  Page : 793--800

Effect of monosodium glutamate on the ovaries of adult female albino rats and the possible protective role of green tea


Ahmed Abozaid Ali, Ghada Hassan El-Seify, Hala Mohammed El Haroun, Mona Abd El Mawla Mohammed Soliman 
 Department of Histology, Faculty of Medicine, Menofyia University, Menoufiya, Egypt

Correspondence Address:
Mona Abd El Mawla Mohammed Soliman
Department of Histology, Faculty of Medicine, Menofyia University, Sheibin El Kom, Menoufiya
Egypt

Objective The aim of this study was to determine the histological, histochemical, and immunohistochemical effects of monosodium glutamate (MSG) on the ovaries of adult female albino rats and the possible protective role of green tea. Background MSG is a commonly used food additive. It plays an important role in the pathogenesis of anovulatory infertility. Materials and methods A total of 35 female adult albino rats were used in this study. The rats were divided into four groups: groups I-IV. Group I was the control group. In group II (MSG treated) 10 rats were treated with MSG at a dose of 4 mg/g body weight by subcutaneous injection daily for 14 days. The rats were killed 24 h after MSG treatment. In group III [combined green tea extract (GTE) and MSG treated] 10 rats were treated with GTE and MSG for 14 days. MSG was given at the same dose as that in group II and GTE was given at 300 mg/kg body weight orally daily. The rats were killed 24 h after MSG and GTE treatment. In group IV (GTE treated) five adult rats were treated with GTE only for 14 days and then killed. Results MSG-treated rats showed degenerative changes of the ovary with many atretic follicles. The stroma appeared vacuolated. The medulla showed multiple vacuoles with congested blood vessels. However, combined treatment of GTE and MSG in group III showed amelioration of the histological changes in the ovary. Conclusion It has been concluded that GTE improves the histological changes caused by MSG in the ovary.


How to cite this article:
Ali AA, El-Seify GH, El Haroun HM, Mohammed Soliman MA. Effect of monosodium glutamate on the ovaries of adult female albino rats and the possible protective role of green tea.Menoufia Med J 2014;27:793-800


How to cite this URL:
Ali AA, El-Seify GH, El Haroun HM, Mohammed Soliman MA. Effect of monosodium glutamate on the ovaries of adult female albino rats and the possible protective role of green tea. Menoufia Med J [serial online] 2014 [cited 2020 Jun 1 ];27:793-800
Available from: http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2014;volume=27;issue=4;spage=793;epage=800;aulast=Ali;type=0