Year : 2014 | Volume
: 27 | Issue : 3 | Page : 538--543
Study of serum prolactin in primary immune thrombocytopenic patients
Sanaa S Gazareen1, Ali Z Glal1, Sabry A Shoeib1, Ahmed A Sonbol2, Mohamed El Hafez1, Heba Y Elkholy1
1 Department of Internal Medicine, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Clinical Pathology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
The aims of this work were to study serum prolactin (PRL) levels in patients with primary immune thrombocytopenia (ITP) and to investigate its possible correlation with disease activity and manifestations.
ITP is a disorder characterized by immune-mediated accelerated platelet destruction and suppressed platelet production. Hyperprolactinemia (HPRL) has been described in many autoimmune diseases such as systemic lupus erythematosus.
Patients and methods
The study was carried out on 40 cases of primary ITP patients (group I) and 50 healthy controls (group II). PRL was measured directly in the serum samples by VIDAS PRL kits using the ELFA technique for all patients and controls.
Moderate HPRL (serum PRL 30-200 ng/ml) was present in eight (20%) of primary ITP patients, but was not present in any of the 50 controls. Among 22 patients with platelet count below 30 000/μl, eight (36.4%) patients had HPRL and 14 (63.6%) patients had normal PRL levels. HPRL was associated with lower platelet counts.
This study shows that HPRL is present in 20% of patients with primary ITP. Also, patients with HPRL have a lower platelet count than patients with normal PRL levels.
Heba Y Elkholy
Hematology Unit, Department of Internal Medicine, Faculty of Medicine, Menoufia University, Menoufia
|How to cite this article:|
Gazareen SS, Glal AZ, Shoeib SA, Sonbol AA, El Hafez M, Elkholy HY. Study of serum prolactin in primary immune thrombocytopenic patients.Menoufia Med J 2014;27:538-543
|How to cite this URL:|
Gazareen SS, Glal AZ, Shoeib SA, Sonbol AA, El Hafez M, Elkholy HY. Study of serum prolactin in primary immune thrombocytopenic patients. Menoufia Med J [serial online] 2014 [cited 2020 Apr 1 ];27:538-543
Available from: http://www.mmj.eg.net/article.asp?issn=1110-2098;year=2014;volume=27;issue=3;spage=538;epage=543;aulast=Gazareen;type=0