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ORIGINAL ARTICLE
Year : 2020  |  Volume : 33  |  Issue : 3  |  Page : 993-997

The value of elevated serum resistin levels as a diagnostic marker in psoriasis


1 Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
3 Department of Dermatology, Andrology and STDs, Menoufia General Hospital, Menoufia, Egypt

Correspondence Address:
Sara E. S. Matar
Menouf City, Menoufia Governorate
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_337_18

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Objective The objective of this study was to assess the value of elevated serum resistin levels as a diagnostic marker in psoriasis. Background Psoriasis is a chronic, recurrent, immune-mediated, inflammatory skin disease. Hormonal as well as metabolic factors may play a role in the pathogenesis of psoriasis. Resistin is an adipose tissue-derived adipokine and is linked to inflammation, immunity, obesity, and insulin resistance. Resistin is considered to be important modulator of chronic inflammation contributing to the development of many disorders, including psoriasis. Several studies have showed that resistin and psoriasis are positively correlated. Patients and methods This case–control study was conducted on 34 patients: 17 patients with psoriasis and 17 age-matched and sex-matched healthy controls during the period from November 2017 to March 2018. All patients were subjected to full history taking, clinical examination, and laboratory investigations. Serum resistin levels were measured by using enzyme-linked immunosorbent assay technique. Results Serum resistin levels were significantly elevated in patients with psoriasis (22.96 ± 14.90) compared with healthy controls (10.66 ± 2.57). There was a significant positive correlation between serum resistin level and each of Psoriasis Area and Severity Index score (r = 0.821, P < 0.001) and duration of disease (r = 0.872, P < 0.001). Conclusion Serum resistin levels were higher in patients with psoriasis compared with healthy controls. The levels were correlated with clinical severity in patients with psoriasis. Therefore, serum resistin level can be used as a diagnostic biomarker for evaluating the clinical status of patients with psoriasis and may predict the occurrence of co-morbidities in patients with psoriasis.


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