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ORIGINAL ARTICLE
Year : 2020  |  Volume : 33  |  Issue : 3  |  Page : 878-881

Free thyroxine and thyroid-stimulating hormone in preterm neonates with respiratory distress syndrome


1 Department of Pediatric, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Neonatology, Samanoud General Hospital, Gharbia, Egypt

Correspondence Address:
Asmaa A. M. M. Zidan
El Mahalla, Gharbia
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_440_18

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Objective To study the level of serum free tetraiodothyronine (FT4) and thyroid-stimulating hormone (TSH) in cases of respiratory distress syndrome (RDS) in preterm neonates and its correlation with other clinical findings. Background RDS is one of the most common respiratory complications of prematurity. The relationship between RDS and thyroid hormones levels was the target of this study. Patients and methods This was a case-control study that included 90 preterm neonates (60 preterm neonates with RDS and 30 healthy preterm neonates with matched gestational age and sex as controls), conducted in the neonatal ICU, Menoufia University Hospital, Egypt, from October 2017 to September 2018. Results Mean value of serum FT4 was statistically significant lower among cases than controls, whereas serum TSH was statistically significant higher among cases than controls. There were statistically significant positive correlations between serum FT4 and gestational age, New Ballard score, weight, Apgar score at 1 min, and Apgar score at 5 min, whereas statistically significant negative correlation between FT4 and Downes score. There were statistically significant positive correlations between serum TSH and Downes score, whereas there were statistically significant negative correlations between serum TSH and gestational age, New Ballard score, weight, Apgar score at 1 min, and Apgar score at 5 min. Conclusion The present study showed that there was a negative significant correlation between serum FT4 level and the occurrence and severity of RDS, and there was a positive significant correlation between serum TSH level and the occurrence and severity of RDS.


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