Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2020  |  Volume : 33  |  Issue : 3  |  Page : 755-759

The association between osteoporosis and diabetic neuropathy in patients with type 2 diabetes


1 Department of Internal Medicine, Faculty of Medicine, Menoufia University, Shibin El-Kom, Menoufia Governorate, Egypt
2 Department of Clinical Pathology, Faculty of Medicine, Menoufia University, Shibin El-Kom, Menoufia Governorate, Egypt

Correspondence Address:
Hytham R Badr
Department of Internal Medicine, Faculty of Medicine, Menoufia University, Shibin El-Kom, Menoufia Governorate
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_380_18

Rights and Permissions

Objective The objective of this study was to evaluate the association between osteoporosis and diabetic peripheral neuropathy in patients with type 2 diabetes mellitus (T2DM). Background Diabetic complications and osteoporotic fractures are two of the most important causes of morbidity and mortality in older patients. There is increased fracture rate associated with T2DM, despite these patients having greater bone mineral density. Osteocalcin, one of the bone turnover markers, is a peptide secreted by bone cells and reflects bone formation and consequently indicates bone remodeling status; which is the major mechanism underlying osteoporosis. Patients and methods This case–control study was done on 78 patients with T2DM. They were classified into two groups. Group I (neuropathy group) included 39 patients with diabetic neuropathy. Group II (control group) included 39 patients without diabetic neuropathy. Dual-energy X-ray absorptiometry (DEXA) and serum osteocalcin measurement were done for both the studied groups. Results There was no significant difference between the two studied groups in the DEXA scan results; the mean least T-score of the neuropathy group was −1.4 and that of the control group was −1.2 (P = 0.27). The mean osteocalcin level of the neuropathy group was 35.8, whereas that of the control group was 13.8, showing significant difference between the two groups (P = 0.03). Conclusion Osteoporosis is more prevalent in T2DM with microvascular complications, and serum osteocalcin level is better in its diagnosis than DEXA scan.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed69    
    Printed1    
    Emailed0    
    PDF Downloaded11    
    Comments [Add]    

Recommend this journal