Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2020  |  Volume : 33  |  Issue : 2  |  Page : 699-705

The prognostic value of Glasgow prognostic score in epithelial ovarian cancer


1 Department of Clinical Oncology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Meet Ghamr Oncology Center, Ministry of Health, Meet Ghamr, Dakahlia, Egypt

Correspondence Address:
Salma M El-Menshawy
Zifta, Gharbia
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_264_19

Rights and Permissions

Objective In this study, the authors assessed the prognostic value of Glasgow prognostic score (GPS) in overall survival (OS) and progression-free survival. Background Inflammation plays an important role in the pathogenesis of ovarian cancer. The GPS is an inflammation-based prognostic score composed of C-reactive protein and albumin. Patients and methods A prospective study was conducted in the Department of Clinical Oncology, Menoufia University, between June 2016 and December 2018. The authors analyzed the clinicopathological characteristics and pretreatment C-reactive protein and serum albumin levels of 57 patients with epithelial ovarian cancer. Time to treatment failure and OS were determined using Kaplan–Meier method. Results High GPS was significantly associated with age, performance status, elevated Ca125 level, advanced stage, ascites, size of residual tumor after the debulking surgery, and platinum sensitivity (P < 0.001). In addition, patients with higher GPS had shorter progression-free survival (P < 0.001) and OS (P = 0.107). However, multivariate analysis revealed that GPS is not an independent prognostic factor in those group of patients. Conclusion High GPS is a poor prognostic factor in patients with epithelial ovarian cancer.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed19    
    Printed0    
    Emailed0    
    PDF Downloaded13    
    Comments [Add]    

Recommend this journal