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ORIGINAL ARTICLE
Year : 2020  |  Volume : 33  |  Issue : 2  |  Page : 694-698

Potential of stem cells for skin regeneration following burn


1 Department of Plastic and Reconstructive Surgery, Faculty of Medicine, Menoufia University, Shebeen El-Kom, Egypt
2 Department of Clinical Pathology, Faculty of Medicine, Menoufia University, Shebeen El-Kom, Egypt
3 Plastic and Reconstructive Surgery Department, El-Mehalla El-Kobra General Hospital, Gharbia, Egypt

Correspondence Address:
Ahmed I. F. Ibrahim
Mehalla El-Kobra, Gharbia 32717
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_48_19

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Objective To evaluate the possible additive effects of the use of stem cells for skin regeneration following superficial burn. Background Stem cell therapy has offered a great method in the management of burns. There are different sources of stem cell, such as adipose tissue-derived stem cells (ADSCS), bone marrow-derived stem cells, umbilical cord-derived stem cells, or amniotic fluid stem cells. We tried to prove the potential of ADSCS in the management of superficial burn. Patients and methods This clinical trial was performed at the Department of Plastic and Reconstructive Surgery, Menoufia University Hospital, from January 2014 to January 2016. It was done on 30 patients with superficial burn. The ages of the patients ranged from 20 to 60 years. Patients were of both sexes, who were divided into two groups: group A was scheduled for application of ADSCS in burnt area after its isolation by liposuction, and group B was scheduled for application of silver sulfadiazine. Results Postoperative follow-up assessment took place on the third, fifth, seventh, 14th, and 21st day. The supervisors and researchers assessed results based on clinical observation and analysis of the preoperative and postoperative photographs, with significant superiority of using ADSCSs with respect to rapid healing, pain tolerance, and patient's satisfaction. Conclusion Adipose tissue-derived mesenchymal stem cell dressing application can be an option and may become an ideal therapy in the treatment of superficial burn. Its use would shorten the period of healing and provide a cheap alternative to other techniques.


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