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ORIGINAL ARTICLE
Year : 2020  |  Volume : 33  |  Issue : 2  |  Page : 405-409

Effect of clomiphene citrate, tamoxifen, and letrozole on endometrial thickness in cycles of ovulation induction: a randomized controlled trial


1 Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Obstetrics and Gynecology, General Administration of Medical Affairs, Mansoura University, Mansoura, Egypt

Correspondence Address:
Sally Nagah Taha
Street 100, New Damietta
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_427_18

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Objectives To compare the effect of clomiphene citrate, tamoxifen, and letrozole on endometrial thickness in anovulatory cycles. Background Infertility is frequently caused by anovulation. The affected women were presented with irregular menstrual cycles and the most common diagnosis was polycystic ovary syndrome. Ovulation induction is commonly used to treat these women. We compare between the three drugs to conclude their efficacy on endometrial thickness, number of follicles, and clinical pregnancy rate. Patients and methods This prospective study was done in Talkha Hospital. One hundred infertile cases meeting the selection criteria especially patients with polycystic ovarian syndrome were included. They were randomized into three groups. Group A (n = 34) took 100 mg clomiphene citrate, group B (n = 33) took 5 mg letrozole, and group C (n = 33) took 40 mg tamoxifen from day 2 to day 6 of the cycle, once after breakfast for three cycles. The outcome measure was endometrial thickness, number of follicles, and clinical pregnancy rate. Results Endometrial thickness was higher in groups B and C than group A, higher number of follicles in group A with no difference regarding the clinical pregnancy rate between the three groups. Conclusion Groups B and C had better effect on endometrial thickness than group A although it had higher number of follicles, clinical pregnancy rate increased with group B than groups A and C.


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