Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2020  |  Volume : 33  |  Issue : 1  |  Page : 94-100

Study of pepsin level in saliva as a noninvasive marker for diagnosis of gastroesophageal reflux disease


1 Department of Gastroenterology and Hepatology, Menoufia University, Shebin El-Kom, Menoufia, Egypt
2 Department of Clinical Pathology, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt
3 Department of Tropical Medicine, Shebin El-Kom, Menoufia, Egypt

Correspondence Address:
Walaa A Shaheen
Shebin El-Kom, Menoufia
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_371_16

Rights and Permissions

Objective This study aimed to evaluate the role of salivary pepsin level as a noninvasive marker for diagnosis of gastroesophageal reflux disease (GERD) and its endoscopic severity. Background GERD is one of the most commonly encountered gastrointestinal diseases. Confirmation of the diagnosis mostly entails the use of invasive procedures. Salivary pepsin level has been discussed previously in studies of extraesophageal symptoms of GERD. Patients and methods This study was conducted on 50 patients with clinical and endoscopic evidences of erosive reflux disease (GERD group) versus 25 patients with upper gastrointestinal symptoms not consistent with GERD and in whom endoscopic findings proved absence of GERD (non-GERD group). In addition, 20 healthy participants were selected as a control group. Patients and control were subjected to GERD Q questionnaire, upper gastrointestinal endoscopy, and quantitative measurement of salivary pepsin using ELISA kits. Results There was a highly significant increase in the mean value of salivary pepsin in GERD group (88.64 ± 46.37 ng/ml) when compared with non-GERD (38.08 ± 35.57) and control group (18.65 ± 14.71) (P = 0.0008 and 0.001, respectively), whereas there was no significant difference (P = 0.226) between non-GERD and control group. There was a highly significant increase (P = 0.0008) in mean value of salivary pepsin in patients with GERD complicated with Barrett's esophagus (152.50 ± 27.12) when compared with patients with GERD without this complication (76.48 ± 38.70). Conclusion Salivary pepsin is a simple noninvasive marker for diagnosis of GERD and its severity.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed52    
    Printed0    
    Emailed0    
    PDF Downloaded8    
    Comments [Add]    

Recommend this journal