Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Year : 2020  |  Volume : 33  |  Issue : 1  |  Page : 89-93

Effect of obesity on YKL-40 serum level to evaluate its role as an independent marker in type 2 diabetic nephropathy

1 Department of Internal Medicine, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Clinical Pathology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
3 Department of Internal Medicine, Ministry of Health, Tanta, Egypt

Correspondence Address:
Fady W. T. Morkos
Department of Internal Medicine, Ministry of Health, Tanta
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mmj.mmj_331_18

Rights and Permissions

Objective The objective of this study was to evaluate the serum YKL-40 level as an independent marker in patients with type 2 diabetic nephropathy (DN). Background DN is a microvascular complication of type 2 diabetes mellitus. The association of YKL 40 serum level with obesity and type 2 DN has not been adequately studied. Patients and methods This study was conducted on 75patients with type 2 DN(25 obese with type 2 DN,25 nonobese patients with type 2 DN,and25 obese without diabetes) fromJuly 2017 to February 2018. Full history, physical examination, serum urea, serum creatinine, estimated glomerular filtration rate (eGFR), glycated hemoglobin 1c (HbA1c), serum YKL-40, urinary albumin/creatinine ratio (ACR) and abdominal ultrasonography were done. Results There was no significant difference among the three groups regarding sex (P = 0.527), drug taking (P = 1.0), age (P = 0.149), and serum urea (P = 0.496), whereas there was a highly significant difference among all groups regarding BMI, YKL 40 serum level, ACR, HbA1c, eGFR, and serum creatinine level (P = 0.001 for all). YKL-40 level was significantly positively correlated with BMI, creatinine level, ACR, and HbA1c and in a negative correlation with eGFR in all groups. Conclusion YKL-40 significantly correlates with biochemical renal parameters like ACR, creatinine, and eGFR; glycemic parameter, HbA1c; and obesity measure, BMI. Our study suggests that YKL-40 can be a marker of microvascular complications such as DN but not an independent marker owing to positive affection of obesity on its serum level.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded36    
    Comments [Add]    

Recommend this journal