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ORIGINAL ARTICLE
Year : 2020  |  Volume : 33  |  Issue : 1  |  Page : 89-93

Effect of obesity on YKL-40 serum level to evaluate its role as an independent marker in type 2 diabetic nephropathy


1 Department of Internal Medicine, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Clinical Pathology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
3 Department of Internal Medicine, Ministry of Health, Tanta, Egypt

Correspondence Address:
Fady W. T. Morkos
Department of Internal Medicine, Ministry of Health, Tanta
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_331_18

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Objective The objective of this study was to evaluate the serum YKL-40 level as an independent marker in patients with type 2 diabetic nephropathy (DN). Background DN is a microvascular complication of type 2 diabetes mellitus. The association of YKL 40 serum level with obesity and type 2 DN has not been adequately studied. Patients and methods This study was conducted on 75patients with type 2 DN(25 obese with type 2 DN,25 nonobese patients with type 2 DN,and25 obese without diabetes) fromJuly 2017 to February 2018. Full history, physical examination, serum urea, serum creatinine, estimated glomerular filtration rate (eGFR), glycated hemoglobin 1c (HbA1c), serum YKL-40, urinary albumin/creatinine ratio (ACR) and abdominal ultrasonography were done. Results There was no significant difference among the three groups regarding sex (P = 0.527), drug taking (P = 1.0), age (P = 0.149), and serum urea (P = 0.496), whereas there was a highly significant difference among all groups regarding BMI, YKL 40 serum level, ACR, HbA1c, eGFR, and serum creatinine level (P = 0.001 for all). YKL-40 level was significantly positively correlated with BMI, creatinine level, ACR, and HbA1c and in a negative correlation with eGFR in all groups. Conclusion YKL-40 significantly correlates with biochemical renal parameters like ACR, creatinine, and eGFR; glycemic parameter, HbA1c; and obesity measure, BMI. Our study suggests that YKL-40 can be a marker of microvascular complications such as DN but not an independent marker owing to positive affection of obesity on its serum level.


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