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ORIGINAL ARTICLE
Year : 2020  |  Volume : 33  |  Issue : 1  |  Page : 288-294

Chemerin levels in patients with coronary artery disease


1 Department of Cardiology, Faculty of Medicine, Menoufia University, Menoufia, Cairo, Egypt
2 Department of Biochemistry, Faculty of Medicine, Menoufia University, Menoufia, Cairo, Egypt
3 Department of Cardiology, Ministry of Health, Cairo, Egypt

Correspondence Address:
Mahmoud A Aboelezz
Mansoura, Dakahlia 35511
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_127_19

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Objectives To evaluate chemerin levels in patients with coronary artery disease and detect the correlation between these levels (if any) with the severity of coronary artery disease. Background Recent evidence demonstrated that the circulating adipokines were associated with the onset of coronary artery disease (CAD). As a novel adipokine; chemerin has been related to atherosclerosis and the presence of coronary artery disease. However, the plasma levels of chemerin in patients with acute coronary syndrome (ACS) have yet to be investigated. Methods This study a prospective case-control study included 96 participates undergoing coronary angiography at cath lab, cardiology department-Menoufia University from January 2018 to September 2018. Serumchemerin levels weremeasured by an enzyme-linked immunosorbent assay (ELISA). Echocardiography, electrocardiography and routine laboratory investigations were done. The severity of coronary stenosis was estimated usingGensini, vessel and severity coronary scores. Results Among the 96 patients, 4groups were described: group I included 24 Acute myocardial infarction (AMI) patients, 30 unstable angina (UA) patients in group II, 27 stable angina (SA) patients inGroup III, 15 patients with normal coronary artery findings (control group) in Group IV. Serumchemerin levels were significantly higher in AMI and UA groups than SAand control groups P < 0.001. Also there was a high significant positive correlation between serum chemerin levels and severity of CAD as regard to Gensiniscore P < 0.001, severity score P < 0.001 and vessel score P = 0.005. Conclusion Chemerin is a novel biomarker for CAD and it was significantly correlated with various metabolic risk factors and atherosclerotic cardiovascular disease.


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