Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2020  |  Volume : 33  |  Issue : 1  |  Page : 283-287

Role of melatonin in constitutional delayed puberty in boys


1 Department of Dermatology, Andrology and STIs, Menoufia University, Menoufia, Egypt
2 Department of Clinical Pathology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
3 Department of Dermatology, Kafr El-Sheikh Dermatology Hospital, Kafr El-Sheikh, Egypt

Correspondence Address:
Nehal K Abdallah
Department of Dermatology, Kafr El-Sheikh Dermatology Hospital, Kafr El-Sheikh
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_300_18

Rights and Permissions

Objective The aim of this work to assess melatonin level in boys with constitutional delayed puberty (CDP) and study its correlation to follicle-stimulating hormone (FSH), total testosterone, and prolactin hormones. Background CDP is a common cause of pubertal delay. These boys have no underlying pathology and will progress normally. Melatonin hormone has an important role in pubertal onset. Before puberty, it is too high for hypothalamic activation. However, at puberty, it drop below threshold value, after which pubertal changes start occurring. Patients and methods This study was carried out on 50 boys aged 14–18 years who were divided into two groups: 25 boys with CDP as a patient group and another 25 age-matched boys with full pubertal development as a control group. All boys were subjected to full history taking, clinical examination, bone age determination, and laboratory investigations (testosterone, FSH, prolactin, and melatonin). Results Our results showed that in CDP, bone age is significantly delayed compared with their chronological age as well as the bone age of control group. Weight and height are significantly less in CDP than control. Both serum total testosterone and FSH are significantly lower in CDP compared with controls, whereas there were insignificant differences in serum prolactin. Melatonin is significantly higher in CDP compared with control. Melatonin is inversely correlated with both testosterone and FSH and has no correlation with prolactin. Conclusion Melatonin is significantly elevated in CDP boys, and it is negatively correlated with hormones of sexual maturation (testosterone) and reproduction (FSH).


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed16    
    Printed0    
    Emailed0    
    PDF Downloaded4    
    Comments [Add]    

Recommend this journal