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ORIGINAL ARTICLE
Year : 2020  |  Volume : 33  |  Issue : 1  |  Page : 210-216

Herpes virus incidence after liver transplantation


1 Department of Clinical Pathology, Faculty of Medicine, Benha University, Benha, Egypt
2 Department of Clinical Pathology, National Liver Institute, Shebein El Kom, Egypt
3 Department of Clinical Pathology, Faculty of Medicine, Menoufia University, Shebein El Kom, Egypt

Correspondence Address:
Wesam E Hamed
Clinical Pathology Department, National Liver Institute, Menoufia University, Shebein El Kom, Menoufia
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_185_19

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Objective To study the incidence of herpes virus infection after liver transplantation (LT). Background Viral infections are common after LT patients; human cytomegalovirus (HCMV) infection is considered as the most frequent one. Human herpes virus 6 (HHV-6) can cause primary infection or reactivation from latency in LT recipients. Many techniques are used for viral load identification. Multiplex real-time PCR reduces test costs, improves turnaround times, and increases test throughput. Patients and methods This study was conducted on 70 patients, comprising 40 LT patients who presented to Surgical Department, National Liver Institute, Menoufia University. and 30 age-matched and sex-matched healthy donors a control group, in the period from 2014 to 2018. HCMV and HHV-6 were determined by multiplex PCR analysis once before and twice (1 and 3 months, correspondingly) after LT. Results Our study detected HCMV in six cases 3 months after LT, whereas HHV-6 was detected in only two cases. Conclusion LT could be associated with increased incidence of HCMV and HHV-6.


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