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ORIGINAL ARTICLE
Year : 2020  |  Volume : 33  |  Issue : 1  |  Page : 196-204

Protective effect of caffeine and curcumin versus silymarin on nonalcoholic steatohepatitis in rats


1 Department of Clinical Pharmacology, Faulty of Medicine, Menoufia University, Shebin El-Kom, Egypt
2 Department of Pathology, Faulty of Medicine, Menoufia University, Shebin El-Kom, Egypt
3 Department of Biochemistry, Faulty of Medicine, Menoufia University, Shebin El-Kom, Egypt
4 Department of Clinical Pharmacology, Faulty of Medicine, Mansoura University, Mansoura, Egypt

Correspondence Address:
Ghada A Hegazy
Shebin El-Kom, Shebin El-Kom
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_253_18

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Objective To compare between the effect of curcumin, caffeine with silymarin on an animal model of nonalcoholic steatohepatitis induced by a high-fat and high-sucrose (HFHS) diet. Background Nonalcoholic fatty liver disease is recognized as the most common cause of chronic liver disease. Pro-inflammatory and anti-inflammatory cytokines play a part in the pathogenesis of nonalcoholic fatty liver disease, oxidative stress, and insulin resistance. Materials and methods Fifty male albino rats were divided into five groups: control group; group B receives a HFHS diet for 16 weeks; group C receives a HFHS diet for 16 weeks and was treated by silymarin in the last 8 weeks; group D receives a HFHS diet for 16 weeks and was treated with curcumin in the last 8 weeks; and group E receives a HFHS diet for 16 weeks and was treated with caffeine in the last 8 weeks. Results The HFHS group shows a significant increase in body weight, insulin, tumor necrosis factor α, malonaldehyde, total cholesterol, and triglycerides; compared with the control group, silymarin-treated, curcumin-treated, and caffeine-treated groups show a significant decrease in these parameters. Conclusion Silymarin-treated, curcumin-treated, and caffeine-treated groups show a significant protection against HFHS (western) diet-induced nonalcoholic steatohepatitis.


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