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Year : 2020  |  Volume : 33  |  Issue : 1  |  Page : 127-131

Prevalence of glucose level abnormalities in neonatal sepsis and its association with mortality

1 Department of Pediatrics, Faculty of Medicine, Menoufia University, Menoufia, Benha, Egypt
2 Department of Pediatrics, Ministry of Health, Benha, Egypt

Correspondence Address:
Abd El Hameed R A. Issa
387 Canal El Suez, El Shatby, Bab Sharq, Alexandria 21111
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mmj.mmj_216_18

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Objective To determine the prevalence of plasma glucose abnormalities among infants with neonatal sepsis and their association with mortality and morbidity. Background Plasma glucose abnormalities were previously noted in neonatal sepsis, but data in full-term neonates is limited and the association with mortality and morbidity is not established. Patients and methods This was a prospective observational study including 114 full-term neonates with culture-proven and probable sepsis. Plasma glucose level was measured within 2 h of neonatal intensive care unit admission and the patients were monitored till discharge or mortality. The patients were divided into three groups according to their plasma glucose level into hyperglycemic, hypoglycemic, and normoglycemic subgroups. Results Of the patients, 8.7% were hyperglycaemic; 8.7% were hypoglycemic, and 82.6% were normoglycemic. Mortality in the hypoglycemic, hyperglycemic, and normoglycemic subgroups were 20, 20, and 17%, respectively (P = 0.8). There was no significant difference in the length of hospital stay according to the glycemic status (P = 0.3). In addition, the glycemic status was not associated with the need for mechanical ventilation (P = 0.99). Conclusion Plasma glucose abnormalities are not uncommon among full-term neonates with sepsis. However, these abnormalities are not associated with morbidity or mortality. Larger studies are needed to confirm these findings.

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