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Year : 2020  |  Volume : 33  |  Issue : 1  |  Page : 116-121

MicroRNA and liver diseases

1 Department of Internal Medicine, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Internal Medicine at Ministry of Health, Sherbeen, Dakahlia, Egypt

Correspondence Address:
Ahmed A Abdalwahab
Sherbeen, Dakahlia
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mmj.mmj_227_18

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Objective The aim was to review and update the relationship between microRNA and various liver diseases such as viral hepatitis, liver cirrhosis, alcoholic liver disease, liver fibrosis, and hepatocellular carcinoma. Background MicroRNAs play an important role in miscellaneous cellular process including development, immunity, cell-cycle control metabolism, viral or bacterial disease, stem cell differentiation, and oncogenesis. Materials and methods Medline databases, including PubMed, Medscape, Science Direct, and EMF-Portal, and all materials available on the internet from 2004 to 2018 were searched. The initial search presented many articles that studied the microRNA and its relation to various liver diseases. If the studies did not fulfill the inclusion criteria, they were excluded. Study quality assessment included whether ethical approval was gained, eligibility criteria specified, appropriate controls mentioned, adequate information provided, and assessment measures defined. Comparisons were made by structured review with the results tabulated. Findings MicroRNAs are recognized to play an important role in diagnosis, prognosis, and treatment in various liver diseases. Conclusion The significance of miRNA regulation in different physiological and pathological conditions is becoming increasingly visible and undeniable. A number of studies have reported the crucial roles that miRNAs exert along the onset and development of various pathologies including acute and chronic liver diseases such as nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, liver fibrosis, liver cirrhosis, and also hepatocellular carcinoma.

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