Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Year : 2019  |  Volume : 32  |  Issue : 3  |  Page : 829-835

Notch signaling in dermatology

1 Department of Dermatology and Andrology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Pathology, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Correspondence Address:
Heba Allah S K Bazid
Department of Dermatology, Faculty of Medicine, Menoufia University, Shibin Elkom, Menoufia
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mmj.mmj_716_17

Rights and Permissions

Objective The aim of this study was to assess the role of Notch signaling in both health skin and pathogenesis and management of skin diseases. Materials and methods PubMed and all materials on the internet from 2000 to 2017 were searched. The initial search presented 101 articles, of which 49 met the inclusion criteria: clinical trial types II and III, published in English language, published in peer-reviewed journals, and focusing on Notch in different skin diseases. If the studies did not fulfill the inclusion criteria, they were excluded. Study quality assessment included whether ethical approval was obtained, eligibility criteria specified, appropriate controls, and adequate information. A structured systematic review was performed. Findings Overall, 49 articles were potentially relevant publications. The studies reported that Notch may have a role in both physiology of the skin and the pathogenesis and treatment of multiple skin diseases. Conclusion Notch signaling has many physiological roles, and understanding its role in the pathogenesis of different skin diseases allows new target for their treatment.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded26    
    Comments [Add]    

Recommend this journal