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Year : 2019  |  Volume : 32  |  Issue : 3  |  Page : 823-828

Acquired von Willebrand syndrome: a systemic review

1 Department of Internal Medicine, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt
2 Department of Internal Medicine, Shebin El-Kom Teaching Hospital, Shebin El-Kom, Menoufia, Egypt

Correspondence Address:
Fatma Noaman
Department of Internal Medicine, Ministry of Health, El-Shohada, Menofia Governorate 32717
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mmj.mmj_11_18

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Objective The aim was to study the relationship between acquired von Willebrand syndrome (AvWS) and other diseases. Materials and methods Medline, Embase, and PubMed databases were searched and also material available in the internet was made use of. The search was performed on 1 May 2016 and included articles published ahead of print with no language restrictions. The search was performed in the electronic databases from 2013 to 2017. The initial search presented 50 articles, papers, and journals. The articles studied the relationship between AvWS and other diseases. Data from each eligible study were independently abstracted in duplicate using a data collection form to capture information on study characteristics, interventions, and quantitative results reported for each outcome of interest. Owing to the heterogeneity of the causes of AvWS, it was not possible to pool the data and carry out a meta-analysis. Significant data were collected. Thus, a structured review was performed with the results tabulated. Findings In total, 10 potentially relevant publications were included. The studies indicate the relationship between AvWS and other diseases, such as monoclonal gammopathy of uncertain significance, and lymphoproliferative and myeloproliferative disorders. Conclusion Excellent outcomes have been achieved on the topic of AvWS and several diseases such as monoclonal gammopathy of undetermined significance, multiple myeloma, essential thrombocytosis, polycythemia vera, and non-Hodgkin's lymphoma.

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