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Year : 2019  |  Volume : 32  |  Issue : 3  |  Page : 818-822

Role of hepcidin in iron metabolism and pathophysiology of different types of anemia

1 Department of Pediatrics, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Pediatrics, Tala Centeral Hospital, Tala, Menoufia, Egypt

Correspondence Address:
Nehal K El Shennawy
Department of Pediatrics, Tala Centeral Hospital, Tala, Menoufia
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mmj.mmj_20_18

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Objectives The study aimed to demonstrate the critical role of hepcidin in regulation of iron metabolism in various types of anemia. Data sources Medline databases (PubMed, Science Direct, Medscape) and all materials available in the Internet from 2007 to 2017 were searched. Study selection The initial search presented 38 articles, of which 11 met the inclusion criteria. The articles studied the relation between hepcidin and iron homeostasis in various types of anemia. Data extraction If the studies did not fulfill the inclusion criteria, they were excluded. Study quality assessment included whether ethical approval was gained, eligibility criteria specified, appropriate controls included, adequate information provided, and assessment measures defined. Data synthesis Comparisons were made by structured review with the results tabulated. Findings In total, 11 potentially relevant publications were included. All were human studies. The studies indicated that hepcidin levels were markedly reduced in cases with thalassemia intermedia, which resulted in iron overload. However, hepcidin levels were increased in cases with anemia of chronic disease, which resulted in decreased bioavailability of iron. Conclusion Hepcidin has key role in iron regulation and pathogenesis of various types of anemia including anemia of chronic disease and anemia with iron overload. Hepcidin may provide promising therapeutic target in cases with dysregulated iron metabolism.

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