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REVIEW ARTICLE
Year : 2019  |  Volume : 32  |  Issue : 3  |  Page : 790-796

Effect of adiponectin and highly sensitive C-reactive protein on the severity of coronary artery disease


1 Department of Cardiology, Menoufia University, Menoufia, Egypt
2 Department of Cardiology, Elsahel Teaching Hospital, Cairo, Egypt

Correspondence Address:
Ahmed O Elsisy
Nasr City, Cairo
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_880_17

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Objective The objective of our study was to estimate the effect of adiponectin (ADPN) and highly sensitive C-reactive protein (hsCRP) level on the severity of coronary artery disease (CAD) in patients with chronic stable angina. Materials and methods MEDLINE databases (PubMed, Journal of Clinical Endocrinology and Metabolism, British Medical Journal, Journal of American College of Cardiology, and European Heart Journal) and also materials available in the internet were searched. The search was performed in the electronic databases from 2000 to 2017. The initial search presented 122 articles of which 29 met the inclusion criteria. The articles studied ADPN, hsCRP, and severity of CAD. If the studies did not fulfill the inclusion criteria, they were excluded. Study quality assessment included whether ethical approval was gained, eligibility criteria specified, appropriate controls, adequate information, and defined assessment measures. Comparisons were made by structured review with the results tabulated. Findings In total, 29 potentially relevant publications were included. The studies indicate an association between ADPN and hsCRP and severity of CAD in patients with CAD. Conclusion ADPN and hsCRP are markers of poor prognosis in patients with CAD.


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