Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Year : 2019  |  Volume : 32  |  Issue : 3  |  Page : 784-789

Evaluation of feline McDonough sarcoma-like tyrosine kinase 3 (CD135) expression in acute myeloblastic leukemia

1 Clinical Pathology Department, Faculty of Medicine, Fever Hospital, Shebin El-Kom, Menoufia, Egypt
2 Oncology Department, Faculty of Medicine, Fever Hospital, Shebin El-Kom, Menoufia, Egypt
3 Clinical Pathology Department, Fever Hospital, Shebin El-Kom, Menoufia, Egypt

Correspondence Address:
Samar S H El-Gazzar
Shanwan, Menoufia 32717
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mmj.mmj_691_17

Rights and Permissions

Objective The aim of this study was to evaluate the role of feline McDonough sarcoma (FMS)-like tyrosine kinase 3 (FLT3) in acute myeloblastic leukemia (AML). Background AML is the most common acute leukemia affecting adults, and its incidence increases with age. FLT3 belongs to the class III receptor kinase family, which plays an essential role in hematopoiesis, driving differentiation of early myeloid and lymphoid lineages. Data sources Medline databases (PubMed, Medscape, Science Direct) and all materials available in the Internet from 1996 to 2017. Study selection The initial search yielded 107 articles, of which 20 fulfilled the inclusion criteria. The articles studied the relation between FLT3 and AML. Data extraction Midline searches with the keywords 'acute myeloblastic leukemia, Feline McDonough Sarcoma like tyrosine kinase, FLT3' in the title of the papers; extraction was performed, including assessment of the quality and validity of papers that fulfilled the previous criteria of FLT3 expression in AML. Data synthesis Each study was reviewed independently; the data obtained were rebuilt in a new language according to the needs of the researcher and categorized into topics throughout the article. Comparisons were made by structured reviews, with the results tabulated. Findings The studies indicated that FLT3 is significantly increased in patients with AML. Conclusion FLT3 overexpression was found in patients with AML and correlated with relapsed cases, worse survival, and poor outcome. This indicated that FLT3 overexpression can be used as a poor prognostic predictor for AML.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded31    
    Comments [Add]    

Recommend this journal