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Year : 2019  |  Volume : 32  |  Issue : 3  |  Page : 777-783

Evaluation of the relationship between glutathione peroxidase 1 polymorphism and hepatocellular carcinoma


1 Department of Clinical Pathology, Faculty of Medicine, National Liver Institute, Menoufia University, Shebin El-Kom, Menoufia Governorate, Egypt
2 Department of Hepatology, National Liver Institute, Menoufia University, Shebin El-Kom, Menoufia Governorate, Egypt
3 Department of Clinical Pathology, National Liver Institute, Menoufia University, Shebin El-Kom, Menoufia Governorate, Egypt

Correspondence Address:
Sara M A Aboagiza
16 Mahmoud Allam Street, Shebin El-Kom 32511, Menoufia Governorate
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_906_17

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Objective The objective of this study was to investigate association of genetic polymorphism of glutathione peroxidase 1 (rs1050450) with liver fibrosis and hepatocellular carcinoma (HCC). Materials and methods Electronic searches were conducted in PubMed, Embase and Cochrane Library from the start of the database to 2017. The initial search presented 215 articles of which 20 met the inclusion criteria. The articles studied the relation between glutathione peroxidase 1 (GPX1) and liver fibrosis and HCC. Extraction was performed, including the assessment of the quality and the validity of the papers that met with the prior criteria that describe the review. If the studies did not fulfil the inclusion criteria, they were excluded. Study quality assessment included when ethical approval was obtained, eligibility criteria defined, sufficient information, convenient controls and known assessment measures. Each study was reviewed independently; the data obtained were rebuilt in a new manner according to the need of the researcher and arranged into topics through the article. Then, comparisons were made with the results tabulated. Results In total, 20 potentially relevant publications were included. The studies indicate a significant association between GPX1 polymorphism and liver diseases. Conclusion We found that the GPX1 Pro198Leu (rs1050450) GPX1 polymorphism plays a major role in liver fibrosis progression and HCC development.


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