Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2019  |  Volume : 32  |  Issue : 3  |  Page : 1126-1131

Study of serum lipid profile before and after hepatitis C virus treatment


1 Department of Tropical Medicine, Faculty of Medicine, Menoufia University, Shebin El-Kom, Egypt
2 Department of Tropical Medicine, Shebin El-Kom Fever Hospital, Shebin El-Kom, Egypt

Correspondence Address:
Marwa M El-Shiekh
Berket El-Sabae, Menoufia
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_141_19

Rights and Permissions

Objective To study the lipid profile in hepatitis C virus (HCV) patients before and after treatment with daclatasvir (DAV)+sofosbuvir (SOF)±ribavirin (RBV) to determine the effect of virus clearance on the lipid profile. Background Chronic HCV infection is associated with lipid and lipid protein metabolism disorders. There is a marked increase in serum low-density lipoprotein-cholesterol (LDL-C) in HCV-infected patients treated with SOF and RBV. Participants and methods A total of 100 chronic hepatitis C patients were included in a case–control study from February 2017 to August 2017. Twenty healthy individuals volunteered as a control group. Lipid profile changes were analyzed at baseline, after the end of treatment, and 12 weeks after treatment. Results Before treatment, the levels of serum LDL-C, cholesterol and triglycerides (TGs) were significantly lower in patients than the controls. At the end of treatment and 12 weeks after treatment with DCV + SOF + RBV, there was a significant increase in serum LDL-C, high-density lipoprotein-cholesterol, cholesterol, and TGs (P = 0.0001, 0.0001, 0.0001, and 0.007), respectively, and there was also a significant increase in patients treated with DCV + SOF (P = 0.035, 0.036, 0.01, and 0.0001), respectively. 100% of the treated patients achieved a sustained viral response (week 24). Conclusion Eradication of HCV was associated with an increase in the serum level of total cholesterol, TGs, LDL-C, and high-density lipoprotein-cholesterol; so follow up of the patient's lipid profile after Hepatitis C virus treatment is very important to avoid hyperlipidemia which is a risk for atherosclerotic heart disease.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed37    
    Printed0    
    Emailed0    
    PDF Downloaded13    
    Comments [Add]    

Recommend this journal