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ORIGINAL ARTICLE
Year : 2019  |  Volume : 32  |  Issue : 3  |  Page : 1104-1107

Correlation between serum tumor necrosis factor-α levels and clinicoradiological severity of tuberculosis


1 Department of Chest, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Medical Biochemistry, Faculty of Medicine, Menoufia University, Menoufia, Egypt
3 Department of Chest, El-Mansoura Chest Hospital, El-Mansoura, Dakahlia, Egypt

Correspondence Address:
Fatma S El-Fakharany
El-Galaa, Mansoura, Dakahlia
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_830_17

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Objective The aim was to assess the level of tumor necrosis factor-α (TNF-α) in patients with active pulmonary tuberculosis (TB) and its relation to BMI; different radiological features whether the lesion is minimally, moderately advanced, and far advanced; and to follow-up the level of TNF-α. Background One of the most important and common complaints of patients with TB, which also affects the immune status, is weight loss. When tuberculous infection occurs, a variety of chemokines and cytokines are secreted from infected cells and tissue macrophages. TNF-α increases early in the disease and takes part in the pathogenesis and prevention of mycobacterial infection. Participants and methods Serum TNF-α was measured in 40 newly diagnosed patients as having active pulmonary TB (group I) and 10 controls (group II). Results Serum TNF-α level was significantly higher in patients with active pulmonary TB than in controls, and there was a highly significant negative correlation between TNF-α level and BMI before and after treatment. Serum TNF-α had insignificant positive correlation with grades of Ziehl–Neelsen stain and chest radiography before and after treatment, and the diagnostic cut-off points of TNF-α was found to be 618.1 pg/ml. Conclusion Serum TNF-α level is higher in patients with TB than in controls. TNF-α plays a role in diminishing appetite, in weight loss, and in increased susceptibility to infection.


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