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ORIGINAL ARTICLE
Year : 2019  |  Volume : 32  |  Issue : 3  |  Page : 1071-1077

Cord blood albumin–bilirubin as a predictor for neonatal hyperbilirubinemia


1 Department of Pediatrics, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Pediatrics, Ministry of Health, Menoufia, Egypt

Correspondence Address:
Wael A El Shafie
Department of Pediatrics, Ministry of Health, Menoufia
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_13_18

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Objective The aim was to evaluate the predictive value of cord blood albumin and bilirubin in identifying infants greater than or equal to 35 weeks for subsequent hyperbilirubinemia. Background Hyperbilirubinemia is the most common cause for readmission during the early neonatal period. Early discharge of healthy term newborns after delivery has become a common practice for socioeconomic reasons. Patients and methods A prospective cohort study was carried out on 75 neonates, greater than or equal to 35 weeks, with 34 female and 41 male neonates, delivered in Menoufia University hospital during the period from June 2016 to December 2017. Full history taking, clinical examination immediately after birth, and laboratory investigations were recorded. Results With cord albumin less than 2.8 g/dl, 81.8% of cases developed significant hyperbilirubinemia, whereas levels greater than 3.3 mg/dl were considered safe with no incidence of hyperbilirubinemia. Moreover, in the total group, the highest sensitivity (83.3%) was for cut-off value of cord bilirubin (CB) at 1.88 mg/dl, with positive predictive value of 72.9%, whereas the highest specificity (84.8%) was for cut-off value of CB–cord albumin at −0.6, with negative predictive value of 74.1. In high-risk group, the highest sensitivity (88.9%), highest positive predictive value (94.1%), highest specificity (85.7%), and negative predictive value (75%), were for cut-off value of CB–cord albumin at − 0.82. Conclusion Cord blood albumin and bilirubin examination can be used as an early useful indicator to predict significantly hyperbilirubinemia in neonates. Researches on large scale should be done for more clarification on the predictive value of cord blood albumin and bilirubin for early prediction of significant hyperbilirubinemia.


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