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Year : 2019  |  Volume : 32  |  Issue : 3  |  Page : 1019-1024

Endothelin-1 gene polymorphism in Egyptian patients with vitiligo

1 Department of Dermatology, Andrology and S.T.Ds, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Medical Biochemeistry, Faculty of Medicine, Menoufia University, Menoufia, Egypt
3 Department of Dermatology, Andrology and S.T.Ds, Alhaud Al-Marsoud Hospital, Cairo, Egypt

Correspondence Address:
Douaa S Alsaadany
Tala, Menoufia
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mmj.mmj_862_17

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Objective The aim was to investigate the association between endothelin-1 (ET-1) gene polymorphism and vitiligo occurrence or increased vitiligo risk in Egyptian population. Background ET-1 is a keratinocyte-derived cytokine, which also has been defined as a strong mitogen and melanogen for human melanocytes and a potent stimulant of melanocyte proliferation, melanogenesis, and migration, implying a link with vitiligo. Patients and methods This study was conducted on 60 female patients with vitiligo. Their ages ranged from 6 to 70 years Overall, 54 cases presented with nonsegmental vitiligo and six cases presented with segmental vitiligo. Moreover, 40 age-matched and sex-matched apparently healthy volunteers with no past, present, or family history of vitiligo were included as a control group. Every case and control underwent detection of genotyping of ET-1 by restriction fragment length polymorphism-PCR. Results AA genotype of ET-1 was significantly associated with cases. It increases the risk of vitiligo by 15.9 folds. GA genotype was prevalent in 36.7% of cases. It increases the risk of vitiligo by 3.3 folds. Conclusion There is an association between ET-1 gene polymorphism and vitiligo occurrence.

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