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ORIGINAL ARTICLE
Year : 2019  |  Volume : 32  |  Issue : 3  |  Page : 1009-1012

Evaluation of serum kisspeptin in infertile men with severe oligospermia


1 Department of Dermatology and Andrology, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia Governorate, Egypt
2 Department of Clinical Pathology, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia Governorate, Egypt
3 Department of Dermatology and Andrology, Shebin El-Kom Teaching Hospital, Shebin El-Kom, Menoufia Governorate, Egypt

Correspondence Address:
Mohammed M El-Meligi
Quesna, Menoufia Governorate
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_769_17

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Objective The aim of this study was to determine whether an abnormality in the serum levels of kisspeptin is associated with oligospermia and male infertility. Background The study of kisspeptin has yielded a new concept on the physiology of the hypothalamic–pituitary–testicular axis and thus the sexual and reproductive functions of men. Patients and methods Our case–control study included 44 male participants aged 20–45 years divided into two groups: a case group composed of 22 infertile men with severe oligospermia and with normal serum levels of testosterone, luteinizing hormone, follicle-stimulating hormone, and prolactin and an age-matched control group composed of 22 fertile men. Serum kisspeptin levels were evaluated by an enzyme-linked immunosorbent assay in both groups. Results The results of our study showed that the serum levels of kisspeptin in the infertile oligospermic group were significantly lower than those of the fertile group. Conclusion Deficiency of serum kisspeptin might be associated with oligospermia and fertility problems.


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