Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Year : 2019  |  Volume : 32  |  Issue : 2  |  Page : 740-744

Mean platelet volume as a diagnostic marker in children with acute hepatitis A

1 Department of Pediatrics, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Pediatrics, Ministry of Health, Quesna Central Hospital, Menoufia, Egypt

Correspondence Address:
Amany F Ismael
22 Negm Street, Quesna, Menoufia
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mmj.mmj_312_18

Rights and Permissions

Objective The aim of this study was to assess the level of mean platelet volume (MPV) in children with acute hepatitis A as compared with the control group. Background MPV is a marker that indicates platelet size, function, and the rate of platelet production and activation. Patients and methods Our study was conducted on 100 Egyptian children, aged from 2 to 14 years (58 male and 42 female) previously diagnosed as having hepatitis A as a patient group and 100 apparently healthy age-matched and sex-matched children as a control group. All of them were subjected to full history, physical examination, C-reactive protein, erythrocyte sedimentation rate, complete blood count, MPV levels, liver function tests (alanine aminotransferase and aspartate aminotransferase), serum bilirubin level (total and direct), prothrombin time, and platelet count. The diagnosis of hepatitis A virus infection was based on antihepatitis A virus immunoglobulin M positivity. Results MPV in the study group was significantly lower than the control group (P < 0.001). The MPV levels revealed no correlation with the alanine aminotransferase and aspartate aminotransferase (P > 0.05), but the MPV level was directly proportionate to the platelet counts (P < 0.05). Our study showed that there was 9% of cases with complications, mainly dehydration. Conclusion This study demonstrated that MPV is a negative acute-phase reactant for children with acute hepatitis A.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded44    
    Comments [Add]    

Recommend this journal