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Year : 2019  |  Volume : 32  |  Issue : 2  |  Page : 470-475

Role of serum leptin as a marker of severity of pre-eclampsia

1 Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia Governorate, Egypt
2 Department of Obstetrics and Gynecology, Shebin El-Kom Teaching Hospital, Shebin El-Kom, Menoufia Governorate, Egypt

Correspondence Address:
Amr S El-Bagoury
Gamal Abd El-Nasr Street, Shebin El-Kom, Menoufia Governorate
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mmj.mmj_97_18

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Objective The objective of this study was to evaluate the role of serum leptin level as a marker of severity of pre-eclampsia (PE). Background PE is a hypertensive disorder in pregnancy that is associated with high blood pressure and proteinuria and develops after 20 weeks of gestation. PE is a major contributor to maternal mortality, complicating 2–8% of pregnancies. Patients and methods This study was conducted at the outpatient clinic and obstetric departments of Shebin El-Kom Teaching Hospital from February 2016 to January 2017. This study included 95 pregnant women, among which 20 were diagnosed as having mild PE (group A) and 45 had severe PE (group B), according to American College of Obstetricians and Gynecologists criteria, and 30 participants with normal pregnancy were taken as a control group (group C). Full history was taken; physical examination and obstetric ultrasound were done; and single blood sample was taken from all groups. The serum leptin level was measured using enzyme-linked immunosorbent assay kits. Results There were no statistical significant differences between the studied groups with respect to the maternal age, parity, and the gestational age. Maternal serum leptin levels were statistically significantly higher (P < 0.001) in the PE groups (43.51±15.49 ng/ml) than in the control group (13.87±4.24 ng/ml). The serum leptin levels were found to be statistically significant higher (P < 0.001) in the severe group (49.37±14.4 ng/ml) than in the mild group (30.32±7.8 ng/ml). Conclusion Maternal serum leptin level is increased in PE. It can be taken independently or along with other parameters as a marker for severity of PE.

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