Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2019  |  Volume : 32  |  Issue : 2  |  Page : 458-464

Comparison study between nifedipine and progesterone as maintenance tocolysis after arrested preterm labor


1 Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Family Planning, Met Khakan Health Center, Menoufia Governorate, Menoufia, Egypt

Correspondence Address:
Elham F El-Sisi
Shebin El-Khom City, Menoufia Governorate
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_915_17

Rights and Permissions

Objective The aim was to compare the efficacy and safety of nifedipine and progesterone for maintenance tocolysis after arrested preterm labor and their perinatal outcomes. Background Preterm birth (before 37 completed weeks of gestation) is a 'major cause of death' and a significant cause of long-term loss of human potential. Maintenance tocolysis is continued tocolysis after arrested preterm labor to prevent the recurrence of preterm labor pains. Patients and methods A prospective randomized comparative clinical study was carried out on 66 pregnant women who had preterm labor (six cases lost to follow-up) and attended the Obstetrics and Gynecology Outpatient Clinic at Menoufia Teaching Hospital during the period from March to August 2017. Detailed history, laboratory investigations, obstetric, and ultrasound follow-up study were performed. Results There was no significant difference (P > 0.5) between nifedipine and progesterone groups regarding maternal age and gestational age on admission (weeks), mode of delivery, and neonatal birth weight. However, there was a statistically significant difference (P ≤ 0.05) regarding mean blood pressure before and after treatment in nifedipine group. Moreover, there were less occurrences of neonatal respiratory distress and neonatal ICU admission in the nifedipine group. Additionally, onset of labor between 24 and 34 and between 34 and 37 weeks was significantly less frequent in progesterone group than in nifedipine group. Conclusion We found a superiority of progesterone over nifedipine for maintenance tocolysis. We would only comment that progesterone looks like a promising drug in this regard, and further large studies are required to establish this fact.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed202    
    Printed8    
    Emailed0    
    PDF Downloaded19    
    Comments [Add]    

Recommend this journal