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ORIGINAL ARTICLE
Year : 2019  |  Volume : 32  |  Issue : 2  |  Page : 417-422

Traumatic brain injury: serum S-100B protein measurement related to neuroradiological findings


1 Department of Anesthesiology, Intensive Care and Pain Management, Faculty of Medicine, Menoufia University, Shebeen El-Kom, Egypt
2 Department of Neurosurgery, Faculty of Medicine, Menoufia University, Shebeen El-Kom, Egypt
3 Department of Critical Care, Sheben El Koum Teaching Hospital, Shebeen El-Kom, Egypt

Correspondence Address:
Ahmed A Metwally
Saad Zaghlol Street, Tala, Menoufia 32611
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_564_17

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Objective The aim of this study was to estimate the level of S-100B protein as a biological marker and to assess its sensitivity in the detection and prediction of outcome of traumatic brain injury (TBI) patients compared with radiological and clinical scores. Background TBI has a tremendous impact on public health. S-100B protein increases in cases of TBI and does not increase in nonbrain injuries. S-100B has been found to correlate with the severity of head injury. Patients and methods The study was a prospective, randomized, controlled study. Forty critical patients were divided into two groups; group I had 20 patients with TBI and group II had 20 patients with head-free trauma. Group I had a sampling of serum S-100B at day 1, 3, 5, and at discharge, and the results were correlated with computed tomography brain findings, Glasgow Coma Scale, and outcome. Group II had a sampling of serum S-100B at day 1, and the result was correlated with the results of group I. Results Significant difference between the results of S-100B in group I and group II was detected (P < 0.001), with higher results of S-100B in TBI patients. Significant difference between the results of S-100B in survival and nonsurvival for patients in group I was detected (P = 0.002), with higher results of S-100B in nonsurvival patients. Significant correlation between the results of S-100B and Glasgow Coma Scale in group I was detected (P = 0.002). Conclusion S-100B is a prognostic marker in TBI, specific to TBI, and not correlated to the findings in computed tomography brain.


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