Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2018  |  Volume : 31  |  Issue : 3  |  Page : 946-951

Study of tumor necrosis factor-α in postdialysis fatigue patients


1 Department of Internal Medicine and Nephrology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Medical Biochemistry, Faculty of Medicine, Menoufia University, Menoufia, Egypt
3 Department of Internal Medicine, El Sahel Teaching Hospital, Cairo, Egypt

Correspondence Address:
Mohamed S.H Aboelmagd
Menouf City, Menoufia Governorate
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_10_18

Rights and Permissions

Objective The aim was to study the tumor necrosis factor-α in postdialysis fatigue (PDF). Background Fatigue is one of the most frequent complaints of dialysis patients and is associated with impaired health-related quality of life. Patients and methods A cross-sectional study was conducted on 50 patients receiving hemodialysis treatment who were divided into two groups: group I included 25 patients with PDF, and group II included 25 patients without PDF. All patients attended the Dialysis Unit at Menoufia University Hospital and El Sahel Teaching Hospital in the period from January to October 2017. Demographic, clinical, and laboratory data were recorded for each patient. Results A total of 50 patients were included in the current study. The mean age of group I was 50.20 ± 13.02 years and of group II was 46.76 ± 13.40 years. There was a statistically significant difference between the studied groups regarding sex (P = 0.045), education levels (P = 0.029), weight change (P = 0.001), predialysis diastolic blood pressure (P = 0.016), postdialysis diastolic blood pressure (P = 0.004), hemoglobin (P = 0.001), calcium (P = 0.035), albumin (P = 0.040), and C-reactive protein (P = 0.007). Conclusion Our results concluded that excessive ultrafiltration, intradialytic hypotension, anemia, hypocalcemia, malnutrition, and C-reactive protein were statistically significantly increased in postdialysis fatigue (PDF) group compared with non-PDF. Moreover, there is a lack of correlation between tumor necrosis factor-α and PDF. Finally, it is crucial to design adequate studies to understand the mechanism of PDF, and more importantly, for developing effective therapeutic strategies.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed264    
    Printed0    
    Emailed0    
    PDF Downloaded16    
    Comments [Add]    

Recommend this journal