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Year : 2018  |  Volume : 31  |  Issue : 3  |  Page : 946-951

Study of tumor necrosis factor-α in postdialysis fatigue patients

1 Department of Internal Medicine and Nephrology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Medical Biochemistry, Faculty of Medicine, Menoufia University, Menoufia, Egypt
3 Department of Internal Medicine, El Sahel Teaching Hospital, Cairo, Egypt

Correspondence Address:
Mohamed S.H Aboelmagd
Menouf City, Menoufia Governorate
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mmj.mmj_10_18

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Objective The aim was to study the tumor necrosis factor-α in postdialysis fatigue (PDF). Background Fatigue is one of the most frequent complaints of dialysis patients and is associated with impaired health-related quality of life. Patients and methods A cross-sectional study was conducted on 50 patients receiving hemodialysis treatment who were divided into two groups: group I included 25 patients with PDF, and group II included 25 patients without PDF. All patients attended the Dialysis Unit at Menoufia University Hospital and El Sahel Teaching Hospital in the period from January to October 2017. Demographic, clinical, and laboratory data were recorded for each patient. Results A total of 50 patients were included in the current study. The mean age of group I was 50.20 ± 13.02 years and of group II was 46.76 ± 13.40 years. There was a statistically significant difference between the studied groups regarding sex (P = 0.045), education levels (P = 0.029), weight change (P = 0.001), predialysis diastolic blood pressure (P = 0.016), postdialysis diastolic blood pressure (P = 0.004), hemoglobin (P = 0.001), calcium (P = 0.035), albumin (P = 0.040), and C-reactive protein (P = 0.007). Conclusion Our results concluded that excessive ultrafiltration, intradialytic hypotension, anemia, hypocalcemia, malnutrition, and C-reactive protein were statistically significantly increased in postdialysis fatigue (PDF) group compared with non-PDF. Moreover, there is a lack of correlation between tumor necrosis factor-α and PDF. Finally, it is crucial to design adequate studies to understand the mechanism of PDF, and more importantly, for developing effective therapeutic strategies.

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