Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Year : 2018  |  Volume : 31  |  Issue : 3  |  Page : 816-821

Metal phosphide poisoning in Menoufia University Hospitals

1 Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Menoufia University, Shebeen El-Kom, Egypt
2 Department of Histology, Faculty of Medicine, Menoufia University, Shebeen El-Kom, Egypt

Correspondence Address:
Amira Abd El-Hamid
Quiesna, Menoufia
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mmj.mmj_1_18

Rights and Permissions

Objective To assess the pattern, severity, and outcome of metal phosphide poisoning cases admitted to Menoufia University Poison and Dependence Control Center (MPCC). Background Over the past years, the consumption of metal phosphide rodenticide has been increasing, causing severe morbidity and elevated mortality. It was the first cause of death in poisoning cases admitted to MPCC during the past 2 years. On phosphides contact with moisture or acids, liberation of phosphine gas leads to widespread organ damage. Phosphine blocks the enzyme cytochrome C oxidase, as a result of which mitochondrial oxidative phosphorylation is inhibited. It also denatures many enzymes involved in cellular respiration and metabolism. Patients and methods A prospective study was conducted on 80 patients with acute zinc and aluminum phosphide (ALP) poisoning who were admitted to MPCC, during the period from the first of September 2015 to the end of February 2016. Results A significant relation was found between zinc phosphide, time passed since exposure, and complaint on arrival (P = 0.04), and a nonsignificant relation between ALP, time passed since exposure, and complaint on arrival was detected (P = 0.1). Highly significant relation was noticed between type of phosphide and both echocardiography and poison severity score (P < 0.001). Relation between type of phosphide and outcome of cases was highly significant. Conclusion Metal phosphide compounds cause very serious manifestations to exposed humans with high mortality, which is especially pronounced in ALP poisoned cases.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded49    
    Comments [Add]    

Recommend this journal