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ORIGINAL ARTICLE
Year : 2018  |  Volume : 31  |  Issue : 3  |  Page : 762-771

Study of interleukin-18 during antiviral therapy for hepatitis C with sofosbuvir, ribavirin, and interferon in Menoufia hospitals


1 Department of Microbiology and Immunology, Faculty of Medicine, Menoufia University, Shebin El-Kom, Egypt
2 Department of Internal Medicine, Faculty of Medicine, Menoufia University, Shebin El-Kom, Egypt
3 Department of Microbiology and Immunology, Shebin El-Kom Fever Hospital, Shebin El-Kom, Egypt

Correspondence Address:
Asmaa T.M Esmaeel
Shebin El-Kom, Menoufia Governorate
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_554_16

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Objectives The objectives of this study were to evaluate the role of interleukin-18 (IL-18) in liver cirrhosis caused by hepatitis C, and to determine the effect of the triple regimen treatment sofosbuvir, ribavirin, and interferon on its serum levels. Background IL-18 is a member of the IL-1 family. Recent studies have suggested that IL-18 plays a role in the pathogenesis of liver damage during acute and chronic hepatitis; furthermore, IL-18 may be involved in the development and progression of liver fibrosis. Patients and methods The present study was carried out on 27 hepatitis C patients and 15 age-matched and sex-matched healthy individuals. All patients were subjected to history taking, complete medical examination, and laboratory investigations for liver and kidney functions. Serum levels of IL-18 were measured by ELISA three times for each patient: the first one was measured before treatment initiation, the second after 1 week of treatment, and the third was measured after 3 months of treatment. Results The serum levels of IL-18 were highly elevated in hepatitis C patients compared with controls (P < 0.001). In addition, we found that serum IL-18 was significantly higher before initiation of treatment, decreased after 1 week of treatment, and it was markedly decreased after 3 months of treatment. Conclusion There is significant elevation in the serum levels of IL-18 in hepatitis C patients. IL-18 concentrations were reduced following a successful course of antiviral treatment.


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