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Year : 2018  |  Volume : 31  |  Issue : 3  |  Page : 1011-1017

Diagnostic value of apolipoprotein A1 in neonatal sepsis

1 Department of Pediatrics, Faculty of Medicine, Menoufyia University, Shebeen El-Kom, Egypt
2 Department of Pediatric, Tala General Hospital, Menoufia, Egypt

Correspondence Address:
Wafaa M Amin Shaban
Tala, Menoufia
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mmj.mmj_193_17

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Objective The aim of this study is to detect the value of apolipoprotein A1 (Apo A1) in the diagnosis and prognosis of neonatal sepsis in neonatal ICU of Menoufia University Hospitals. Background Neonatal sepsis is used to describe the inflammatory response to infection in neonates younger than 30 days of age. Apo A1 is the major protein component of high-density lipoprotein in plasma, which decreases during the inflammatory process. Patients and methods Our study was carried out on 60 neonates admitted to neonatal ICU of Menoufia University Hospitals from April 2015 to April 2016 and were divided into two groups: group I (cases) included 40 neonates with a positive clinical and hematological sepsis score and group II (controls) included 20 healthy neonates with no evidence of sepsis. The two groups were subjected to assessment of history, clinical examination, and laboratory investigations in the form of complete blood counts, blood cultures, C-reactive protein, and Apo A1 level. Results Apo A1 level was lower in group I (55.33 ± 1.53 mg/dl) than in group II (85.20 ± 1.69 mg/dl) and the best cut-off point to detect sepsis is 80 mg/dl with a sensitivity of 100% and a specificity of 100%. Conclusion Apo A1 was found to be a diagnostic and prognostic factor in neonates with sepsis.

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