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Year : 2018  |  Volume : 31  |  Issue : 3  |  Page : 1005-1010

High-mobility group box 1 protein serum level in children with febrile seizures

1 Department of Pediatrics, Faculty of Medicine, Menoufia University, Giza, Egypt
2 Department of Pediatrics, El Sheikh Zayed Specialized Hospital, 6thof October, Giza, Egypt

Correspondence Address:
Mohamed M Debdeb
Department of Pediatrics, El Sheikh Zayed Specialized Hospital, 6th of October, Giza
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mmj.mmj_156_17

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Objective The aim of the work was to assess the level of high-mobility group box 1 (HMGB1) protein in the serum of children with febrile seizures (FS) versus other groups of children suffering from afebrile seizures or febrile children without seizures in order to detect the relationship between HMGB1 and FSs. Background FS is considered as one of the most common seizure types during childhood. Fever is induced by increased HMGB1 level during infection and this may induce the development of FSs. HMGB1 is a highly conserved protein found in the nuclei and cytoplasm of nearly all cell types. HMGB1 is considered to be a key mediator of inflammatory diseases. Patients and methods This case–control study was held at Menoufia University Hospital on 80 children from January 2016 to July 2016. Our population was classified into four groups: the FS group (n = 20), febrile children without seizures (n = 20), afebrile seizure patients (n = 20), and healthy controls (n = 20). All groups were subjected to history taking, complete neurological examination, and laboratory investigations [serum blood (sodium, potassium, calcium, blood urea nitrogen, and creatinine), C-reactive protein, complete blood count, and serum HMGB1]. Results Serum HMGB1 was significantly higher in the FS group of children than in other groups. Conclusion From this study we conclude that serum HMGB1 was significantly higher in patients with FSs. Our data suggest that HMGB1 may contribute to the generation of FSs.

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