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ORIGINAL ARTICLE
Year : 2018  |  Volume : 31  |  Issue : 1  |  Page : 12-17

Effect of ondansetron on hypotension andbradycardia associated with spinal anesthesia during cesarean section


1 Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Shibin Elkom, Egypt
2 Department of Anesthesiology and ICU, Faculty of Medicine, Menoufia University, Shibin Elkom, Egypt
3 Department of Obstetrics and Gynecology, Al-Shohada Central Hospital, Menoufia, Egypt

Correspondence Address:
Mai I AbdelHamid
Department of Obstetrics and Gynecology, Al-Shohada Central Hospital, Al-Shohada, Menoufia 32511
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-2098.234215

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Objective The aim of the study was to evaluate the efficacy of ondansetron during spinal anesthesia for cesarean section in overcoming the associated nausea, vomiting, bradycardia, and hypotension. Background Ondansetron, a widely used antiemetic and serotonin antagonist, has been safely used to blunt the Bezold–Jarisch reflex, resulting in less bradycardia and hypotension in humans undergoing spinal anesthesia. Patients and methods One hundred parturients scheduled for elective cesarean section were randomly allocated into two groups. Before induction of spinal anesthesia groupI(n=50) received intravenous ondansetron 4mg and groupII(n=50) received normal saline. Blood pressure, heart rate(HR), nausea and vomiting, shivering, vasopressor requirements, and Apgar score at 1 and 5min were assessed. Results Decreases in systolic arterial pressure were significantly lower in groupI than in groupII. Patients in groupI had significantly less requirement for vasopressor(P=0.005), needed lower dose of vasopressor(P=0.01), and had significantly lower incidences of nausea and vomiting (P=0.03). Decreases in HR were significantly lower in groupI than in groupII just after spinal anesthesia(P=0.02), at 20min(P=0.01), and 50min(P=0.02). Decreases in mean blood pressure were significantly lower in groupI than in groupII just after spinal anesthesia(P=0.007). Conclusion In parturient women undergoing elective cesarean section, intravenous 4mg ondansetron significantly decreased the hypotension, HR fluctuation, and vasopressor doses used.


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