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ORIGINAL ARTICLE
Year : 2017  |  Volume : 30  |  Issue : 4  |  Page : 1244-1249

The clinical significance of serum anti-heat-shock protein 27 antibody levels in β-thalassemia patients


1 Department of Pediatrics, Faculty of Medicine, Menoufia University, Shebeen El-Kom, Egypt
2 Department of Clinical and Chemical Pathology, Faculty of Medicine, Menoufia University, Shebeen El-Kom, Egypt
3 Department of Pediatrics, Damanhur Medical Institute, Damanhur, Egypt

Correspondence Address:
Shereen M El-Shazly
Department of Pediatrics, Damanhur Medical Institute, Damanhur, El-Beheira
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_244_17

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Objective The aim of this study was to measure serum anti-heat-shock protein 27 (HSP27) antibody levels in β-thalassemia patients and to assess the potential associations with the clinical and laboratory characteristics in these patients. Background β-Thalassemia syndromes are one of the most common quantitative hemoglobinopathies. HSP27 is a protein that is produced by the cells as a result of exposure to oxidative stress. Anti-HSP27 antibodies are formed as a result of autoimmune response against HSP27 and they are responsible for the pathogenesis of various disorders. Patients and methods In this study, we analyzed serum anti-HSP27 antibody levels in 60 β-thalassemia patients (30 β-thalassemia major and 30 β-thalassemia intermedia patients) who were recruited from the Pediatric Department, Menoufia University Hospitals, in the period between January 2016 and May 2016. In addition, 30 healthy children matched for age and sex were included as controls. Results Significantly higher serum levels of anti-HSP27 antibodies were found in β-thalassemia patients compared with the controls (P < 0.001). The levels of anti-HSP27 antibodies showed a significantly positive correlation with serum ferritin (r = 0.568; P < 0.001) and serum bilirubin (r = 0.321; P = 0.01) and a significantly negative correlation with age at first diagnosis of thalassemia (r=−0.763; P < 0.001) and the interval of blood transfusions (r=−0.775; P < 0.001). Conclusion Serum anti-HSP27 antibody may be a useful biomarker of oxidative stress in patients with β-thalassemia.


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