Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2017  |  Volume : 30  |  Issue : 4  |  Page : 1110-1116

Potential protective effects of trimetazidine and quercetin on isoprenaline-induced myocardial infarction in rats


1 Department of Clinical Pharmacology, Faculty of Medicine, El-Mansoura University, Mansoura, Egypt
2 Department of Pathology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
3 Department of Clinical Pharmacology, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Correspondence Address:
Doaa Z Mohammad Shebl
Department of Clinical Pharmacology, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_183_17

Rights and Permissions

Objective The aim of this study was to investigate the protective effects of trimetazidine (TMZ), quercetin, and their combination on isoprenaline (ISO)-induced myocardial infarction (MI) in rats. Background ISO has been found to produce MI in large doses; it generates highly cytotoxic free radicals that produce severe damage to the myocardial membrane. Pretreatment with TMZ and quercetin reduce oxidative stress induced by ISO. Materials and methods Fifty adult rats were divided into five groups (n = 10). Group 1 (control) and group 2 (ISO-treated) received normal saline orally through a orogastric tube for 14 days and subcutaneously for the last 2 days. Group 3 (quercetin–ISO treated) received quercetin (50 mg/kg; orally), group 4 (TMZ–ISO treated) received TMZ (10 mg/kg; orally), and group 5 (quercetin-treated and TMZ–ISO treated) received combined drugs for 14 days. All groups except the control group received ISO (100 mg/kg; subcutaneously) in the last 2 days. Serum separation and estimation of highly sensitive cardiac troponin-I, C-reactive protein, serum malondialdehyde, and total serum antioxidant were performed. In addition, histopathological changes of the rat heart were assessed. Results The ISO-treated group showed increased serum levels of highly sensitive cardiac troponin-I, C-reactive protein, and malondialdehyde and decreased serum levels of total serum antioxidant, pathological picture of MI by hematoxylin and eosin staining, and negative myoglobin expression. These parameters improved better in the group receiving combined drugs compared with rats receiving TMZ or quercetin alone. Conclusion The combined treatment showed better synergistic antioxidant and anti-inflammatory effects compared with either treatment alone.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed218    
    Printed5    
    Emailed0    
    PDF Downloaded37    
    Comments [Add]    

Recommend this journal