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ORIGINAL ARTICLE
Year : 2017  |  Volume : 30  |  Issue : 4  |  Page : 1065-1071

The value of osteopontin and matrix metalloproteinase-3 in the assessment of bone mineral density in postmenopausal women


1 Department of Biochemistry, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt
3 Department of Clinical Pathology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
4 Department of Internal Medicine, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Correspondence Address:
Seham A Khodeer
Department of Clinical Pathology, Faculty of Medicine, Menoufia University, Menoufia
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mmj.mmj_41_17

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Objective The aim of this study was to assess the value of osteopontin (OPN) and matrix metalloproteinase-3 (MMP-3) in the assessment of bone mineral density (BMD) in postmenopausal women. Background Osteoporosis is a widespread age-related skeletal disorder characterized by bone loss that increases skeletal fragility. Patients and methods This study was conducted on 172 postmenopausal female individuals. OPN and MMP-3 were assayed by enzyme-linked immunosorbent assay. BMD assessment was carried out by dual-energy X-ray absorptiometry. The patients were divided into three groups according to BMD: osteopenic, osteoporotic and control groups. Results OPN and MMP-3 levels were significantly greater in the osteoporotic and osteopenic groups than in the control group (P < 0.001). In the osteoporotic group, negative correlations between OPN, calcium, and BMD were found as well as positive correlations between OPN and MMP-3. By using the receiver operating characteristic curve, the sensitivities of both OPN and MMP-3 were found to be equal (93%), and the specificities were 100 and 84%, respectively. Conclusion OPN and MMP-3 were significantly increased in postmenopausal women with osteoporosis, suggesting their role in bone turnover. The preserving of normal bone mass density is a challenge for postmenopausal women to prevent bone disabilities. Hence, further studies are recommended to use the presence of OPN and MMP-3 as a regular monitoring system – being sensitive and easy to measure – for the early detection of osteoporosis in postmenopausal women.


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