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REVIEW ARTICLE
Year : 2017  |  Volume : 30  |  Issue : 1  |  Page : 6-9

Liver X receptor α: does it have a role in the pathogenesis of vitiligo?


1 Department of Dermatology, Faculty of Medicine, Menoufia University, Minufya, Egypt
2 Department of Pathology, Faculty of Medicine, Menoufia University, Minufya, Egypt
3 Residant Doctor of Dermatology, Kafr El-Sheikh Health Sector, Metoubes, Egypt

Correspondence Address:
Sherin M Atallah
Motobes, Kafr El-Sheikh, Metoubes, 33511
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-2098.211507

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The aim of the work was to highlight liver X receptor α (LXR-α) and its role in the pathogenesis of vitiligo. Data were obtained from medical text books, medical journals, and medical websites, which had updated investigations with the keywords (liver X receptors and vitiligo) in the title of the papers. Selection was carried out by supervisors for studying LXR-α and its role in the pathogenesis of vitiligo. A special search was carried out for the keywords liver X receptors and vitiligo in the title of the papers. Extraction was carried out and included assessment of the quality and validity of papers that met with the prior criteria described in the review. The main result of the review and each study was reviewed independently. The obtained data were translated into a new language based on the need of the researcher and have been presented in various sections throughout the article. We now know that LXR-α plays an important role in the pathogenesis of vitiligo through its effect on melanogenesis and also through its role in keratinocyte proliferation and apoptosis that affect growth and/or melanization of surrounding melanocytes. In total 54 potentially relevant publications were included, 34 were human and 20 were animal studies. The studies indicate an association between LXR-α and vitiligo pathogenesis as LXRs affect melanogenesis through its effect on genes involved in melanogenesis and also through its role on keratinocyte death, which leads to a decrease in several keratinocyte-derived mediators and growth factors supporting the growth and/or melanization of surrounding melanocytes.


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