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ORIGINAL ARTICLE
Year : 2016  |  Volume : 29  |  Issue : 4  |  Page : 936-943

Effect of sleep deprivation on vascular reactivity in male rats


1 Physiology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
2 Clinical Physiology Department, Faculty of Medicine, Menoufia University, Cairo, Egypt

Correspondence Address:
Ahmad M Gaafar
Clinical Physiology Department, Faculty of Medicine, Menoufia University, Shibin Elkom, 32511
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-2098.202530

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Objective The aim of this study was to evaluate the effect of sleep deprivation on vascular reactivity in adult male albino rats. Background Sleep deprivation can be due to either insufficient duration of sleep or a fragmented sleep period or a combination of both factors. Materials and methods This study was conducted on 140 adult male rats. Rats were divided into four groups: group 1, the control group; group 2, the sleep-deprived group; group 3, the 24-h sleep recovery group; and group 4, the 48-h sleep recovery group. Arterial blood pressure was measured. Vascular reactivity to noradrenaline, indomethacin, vasopressin, ACh, and sodium nitroprusside and the levels of serum adrenaline, noradrenaline, adrenocorticotropic hormone, cortisone, and C-reactive protein (CRP) were studied. Results Induction of sleep deprivation was associated with a significant increase in arterial blood pressures and vascular reactivity to noradrenaline, vasopressin, and indomethacin. The percentage of vasodilation to ACh significantly decreased. Serum levels of adrenaline, noradrenaline, ACTH, cortisone, and CRP significantly increased. In the 24-h recovery group, arterial blood pressures significantly elevated. Vascular reactivity to noradrenaline, vasopressin, and indomethacin were still significantly high. CRP was also still significantly elevated, whereas adrenaline and noradrenaline returned to control levels. In the 48-h recovery group, blood pressure, vascular reactivity, CRP, adrenaline, and noradrenaline returned to control levels. Conclusion Twenty-four-hour recovery period was not sufficient to restore normal vascular reactivity, whereas 48-h recovery period was essential to restore normal vascular reactivity after acute total sleep deprivation.


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