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ORIGINAL ARTICLE
Year : 2016  |  Volume : 29  |  Issue : 2  |  Page : 373-378

Contribution of the STAT4 gene single nucleotide polymorphism to systemic lupus erythematosus


1 Clinical Pathology Department, Menoufiya University, Shebein El-kom, Menoufiya, Egypt
2 Clinical Pathology Department, Ain Shams University, Shebein El-kom, Menoufiya, Egypt
3 Clinical Pathology Department, Tanta University, Faculty of Medicine, Menoufiya University, Shebein El-kom, Menoufiya, Egypt

Correspondence Address:
Ahmed S Hasab El-Naby
Tanta University, Tanta, 31511
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-2098.192430

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Objectives: We investigated the prevalence of the STAT4 G > C (rs7582694) polymorphism in patients with systemic lupus erythematosus (SLE) and controls in a sample of the Egyptian population. Background: STAT4 has been found to be a susceptible gene in the development of SLE in various populations. Participants and methods: The presence of the STAT4 G>C (rs7582694) polymorphism was determined by PCR-RFLP. Results: There was an insignificant difference between SLE patients and controls in their phenotypes (P> 0.05). Also, the distribution of the polymorphism among the SLE patients in terms of different symptoms and the anti-dsDNA titer showed an insignificant difference (P> 0.05). Conclusion: There is no association between the STAT4 G>C (rs7582694) polymorphism and susceptibility for SLE in the population of Egypt that may be different from other populations in geographic location, together with the racial and ethnic differences, and also environmental factors, with differences in lifestyle.


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