Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2016  |  Volume : 29  |  Issue : 2  |  Page : 291-296

Multidetector computed tomography in the detection of hepatocellular carcinomas meeting the Milan criteria before liver transplantation


1 Department of Radiology, Faculty of Medicine, Menoufia University, Shebin El Kom, Egypt
2 Department of Radiology, National Liver Institute, Menoufia University, Shebin El Kom, Egypt

Correspondence Address:
Sarah A Mohammed
Radiology Department, National Liver Institute, Menoufia University, 5 Taisser Street, Shebin El Kom, Menoufia Governorate, 32511
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-2098.192448

Rights and Permissions

Objective: The purpose of this study was to assess the diagnostic performance of multidetector computed tomography (MDCT) in the detection of hepatocellular carcinoma (HCC) in cirrhotic patients who are recommended for liver transplantation according to the Milan criteria. Background: Liver transplantation has been considered to be the only causal treatment for patients with liver cirrhosis and HCC because of its theoretical advantage of eliminating both the tumor and liver disease. However, because of the shortage of donor organs, it is strongly recommended that liver transplantations be performed on cirrhotic patients with HCCs only when the patients meet the predetermined criteria. Imaging is thus decisive in the inclusion or exclusion of patients from transplantation lists. Patients and methods: This study included 35 patients (29 male and six female) with ages ranging from 39 to 60 years presented to the Transplantation Unit of the National Liver Institute, Menoufia University, during the period between May 2013 and December 2014. Potential recipients with focal lesion on their ultrasound underwent triphasic computed tomography. After liver transplantation, the imaging findings were correlated with histopathological findings in the explanted livers on a patient-by-patient and a lesion-by-lesion basis. Results Histopathologic examination revealed 46 HCCs in 31 of 35 patients, whereas MDCT revealed 42 HCCs in 30 of 35 patients. A patient-by-patient analysis showed that the sensitivity of MDCT in the detection of HCC was 90.3%, its specificity was 50%, and its accuracy was 85.7%. Conclusion: MDCT has reasonable sensitivity and high diagnostic accuracy in the detection of HCC in cirrhotic patients indicated for liver transplantation according to the Milan criteria.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed469    
    Printed0    
    Emailed0    
    PDF Downloaded43    
    Comments [Add]    

Recommend this journal